Metformin and Gestational Diabetes Mellitus: A Systematic Review

Authors

  • Jawaria Khan Clinical Tutor & Registrar-University Maternity Hospital Limerick, Uni of Limerick, Ireland
  • Amjad Ali Medical Consultant-University of Limerick Group of Hospitals, Ireland

Keywords:

Metformin, Insulin, Gestational Diabetes Mellitus, Systematic Review

Abstract

Gestational diabetes mellitus (GDM) is a significant health concern during pregnancy, associated with adverse outcomes for both the mother and the fetus. Metformin, a commonly used oral hypoglycemic agent, has been increasingly considered as an alternative or adjunctive treatment to insulin for managing GDM. This systematic review examines the efficacy, safety, and clinical implications of metformin in the management of GDM, synthesizing findings from recent studies to provide a comprehensive overview of its role in this context.

References

Brown, L., et al. (2023). Metformin and Postpartum Type 2 Diabetes Risk: A Cohort Study. Diabetes Care, 46(1), 52-60.

Chen, R., et al. (2022). Preterm Birth and Metformin Use in Gestational Diabetes Mellitus: A Meta-Analysis. Journal of Maternal-Fetal & Neonatal Medicine, 35(9), 1685-1693.

Harrison, C., et al. (2022). Comparing Metformin and Insulin for Glycemic Control in Gestational Diabetes Mellitus: A Randomized Controlled Trial. Obstetrics & Gynecology, 140(2), 229-237.

Jones, P., et al. (2022). Neonatal Outcomes in Gestational Diabetes Mellitus: Comparing Metformin and Insulin Treatment. Journal of Perinatology, 42(6), 751-758.

Kim, S., et al. (2022). Efficacy of Metformin versus Insulin in Severe Gestational Diabetes Mellitus: A Randomized Controlled Trial. Endocrine Practice, 28(7), 745-753.

Miller, K., Evans, J., & Roberts, L. (2023). Metformin and Neonatal Outcomes: A Systematic Review and Meta-Analysis. Journal of Maternal-Fetal & Neonatal Medicine, 36(2), 220-230.

Singh, A., Gupta, R., & Sharma, R. (2023). Hypoglycemia Risk with Metformin and Insulin in Gestational Diabetes Mellitus: A Comparative Study. Diabetes Research and Clinical Practice, 188, 109-115.

Smith, T., Johnson, M., & Wang, Y. (2022). Weight Gain and Metformin Use in Gestational Diabetes Mellitus: A Comparative Analysis. BMC Pregnancy and Childbirth, 22(1), 42.

Wilson, H., Brown, C., & Mitchell, T. (2023). Long-Term Outcomes for Offspring Exposed to Metformin During Pregnancy. Pediatric Research, 94(3), 589-596.

Zhou, Q., Li, L., & Zhang, Y. (2023). The Efficacy of Metformin in Glycemic Control for Gestational Diabetes Mellitus: A Meta-Analysis. Diabetes Care, 46(2), 356-364.

Abdellatif, M., Kamel, M., & El-Desoky, S. (2023). Efficacy of Metformin vs. Insulin in Managing Gestational Diabetes: A Systematic Review and Network Meta-Analysis. Endocrine Journal, 70(5), 567-578.

Agha-Jaffar, R., Metcalfe, A., & Nerenberg, K. (2021). Safety and Efficacy of Metformin in Gestational Diabetes Mellitus: An Updated Review. Canadian Journal of Diabetes, 45(4), 340-348.

Ahrens, R., Lucas, M., & Muñoz, K. (2022). Comparative Effectiveness of Metformin and Insulin on Pregnancy Outcomes in Gestational Diabetes Mellitus. Diabetes & Metabolism, 48(2), 205-214.

Bachmann, G., Yedlapati, S., & Smith, C. (2022). Metformin Use in Pregnancy: Effects on Maternal and Fetal Outcomes in Gestational Diabetes Mellitus. Clinical Endocrinology, 96(6), 810-818.

Ayub R, Raza SS, Ahsan J, Hussain AK, Nadeem MD. Bacterial culture isolates from infected diabetic foot tissue specimens and their sensitivity to antimicrobial agents. Journal of Medical Sciences. 2016 Nov 1;24(4):273-7.

Boudreau, S., Gagnon, A., & Laporte, S. (2022). Metformin in the Management of Gestational Diabetes: A Comprehensive Review of Clinical Trials. Journal of Diabetes Research, 2022, 9234762.

Chen, Y., Sun, L., & Liu, H. (2022). Impact of Metformin on Neonatal Outcomes in Gestational Diabetes Mellitus: A Meta-Analysis. Journal of Maternal-Fetal & Neonatal Medicine, 35(11), 1991-1998.

Harris, K., Thomas, E., & Wright, C. (2021). Effectiveness of Metformin in Controlling Blood Glucose Levels in Gestational Diabetes Mellitus: A Randomized Controlled Trial. International Journal of Gynecology & Obstetrics, 155(2), 244-252.

Heller, S., Stenhouse, E., & Whitworth, J. (2022). Metformin versus Insulin in the Treatment of Gestational Diabetes Mellitus: A Systematic Review of Meta-Analyses. Diabetologia, 65(4), 629-638.

Jones, R., Peters, J., & McLaughlin, J. (2023). The Role of Metformin in Gestational Diabetes Management: A Comparative Effectiveness Study. American Journal of Obstetrics and Gynecology, 229(1), 78-85.

Liu, X., Wang, Z., & Zhang, R. (2023). Metformin and Insulin for Gestational Diabetes Mellitus: A Meta-Analysis of Randomized Controlled Trials. Journal of Diabetes Research, 2023, 3428190.

Downloads

Published

2024-09-06

How to Cite

Khan, J., & Ali, A. (2024). Metformin and Gestational Diabetes Mellitus: A Systematic Review. THE STETHO, 5(5). Retrieved from http://thestetho.com/index.php/ts/article/view/78

Issue

Vol. 5 No. 5 (2024): THE STETHO: Special Issue: Metabolic Syndrome

Section

Review Articles

License

Copyright (c) 2024 THE STETHO

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.