TREATMENT MODALITIES OF INFLAMMATORY BOWEL DISEASE (IBD)

Abstract

A chronic disease of the intestine in genetically susceptible individuals, Inflammatory bowel disease (IBD) is caused by contributing elements of both innate and adaptive immune system. IBD is a group of inflammatory conditions of the bowel that is chronic and uncontrolled in nature. The triggers that start and sustain this constant irritation are the subject of much hypothesis and exploration, in spite of the fact that the focal function of the microbiota (intestinal) is perceived, and is even an objective for treatment in certain conditions. The modern day IBD treatment is targeted at concealing safe reaction towards so far unknown antigens, and customary treatment that includes 5‐aminosalicylic acid (5‐ASA), thiopurines, corticosteroids and methotrexate. Although a complete cure for IBD is not yet available but ongoing revelations in the field of neurosciences and immunology have uncovered that signals in the fringe sensory system direct irritation, including levels of TNF‐α show promising results. Clinical examinations utilizing vagus nerve embedded triggers for IBD treatment show empowering results. As needs be, the reflex control (neural) of aggravation is developing as a possible remedial objective in treating IBD. Here, we audit available and current treatment choices. These include the use 5-ASA, Glucocorticosteroids, Methotrexate and Thiopurines.